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Sesame (Sesamum Indicum)

Sesame (Sesamum Indicum)

Sesamum Indicum Extract Oil derived from sesame (Sesamum indicum, belonging to the Family Pedaliaceae) is highly regarded as a nutritious food source due to its rich nutritional content and stability. Sesame seeds also contain two unique compounds, sesamin and sesamolin, which are known to have a positive impact on cholesterol levels and blood glucose regulation in humans.
 
Therapeutic Uses
  • Supports the maintenance of healthy blood glucose levels.
  • Helps in maintaining healthy cholesterol levels.
  • Contributes to cardiovascular well-being.
  • May be beneficial in weight management.
 
➢ Findings from Animal Studies
  • Research involving rats with high cholesterol levels showed that the administration of sesamin for a period of seven weeks led to a significant decrease in total serum cholesterol, triglycerides, LDL cholesterol, and apolipoprotein-B levels. Conversely, it increased levels of high-density lipoprotein cholesterol (HDL) and apolipoprotein-A.
  • Studies suggest that dietary sesame may have beneficial effects on blood lipids and enhance antioxidant capacity in patients with high cholesterol.
  • Supplementation with sesamin in the diet of rats with high lipid levels resulted in a reduction of total cholesterol and LDL cholesterol concentrations in both plasma and the liver.
  • Treatment with an 18% sesamin protein isolate for 28 days demonstrated cholesterol-lowering activity by reducing cholesterol concentration in the blood, increasing HDL cholesterol, and also decreasing lipid peroxidation in plasma and erythrocyte membranes in rats, both with and without a high-cholesterol diet.
  • Administration of sesame seed powder to rats with high cholesterol led to a significant reduction in total lipids and cholesterol levels in the blood and liver, as well as a decrease in plasma LDL cholesterol levels, accompanied by an increase in plasma HDL cholesterol levels.
 
➢ Findings from Human Studies
  • A diet supplemented with sesame seeds for 60 days significantly lowered levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), and lipid peroxidation in the blood of individuals with high cholesterol. It also improved their antioxidant status.
  • Treatment with sesamin capsules, each containing 2.9 mg of sesamin and 2.3 mg of α-tocopherol in 445 mg of wheat germ oil, for 8 weeks resulted in decreased serum total cholesterol (from 208.6 mg/dl to 198.2 mg/dl) and low-density lipoprotein (LDL) (from 122.7 mg/dl to 111.7 mg/dl) levels in patients with high cholesterol who also had non-insulin-dependent diabetes mellitus.
  • Daily oral intake of sesamin for 4 weeks significantly reduced total and LDL cholesterol concentrations in individuals with high cholesterol.
  • A study conducted with a double-blind design involved 44 patients with type II diabetes. Participants were randomly assigned to either an intervention group or a control group. The intervention group received a daily dose of sesamin (200 mg capsules), while the control group received a placebo. Comparison of various health markers before and after the intervention indicated that sesamin significantly lowered fasting blood sugar (FBS) levels in the intervention group. A significant decrease was also observed in total cholesterol (TC) (141.50±29.03 versus 164.54±45.96 mg/dl) (p=0.015) and LDL-C (73.86±18.34 versus 89.22±32.96 mg/dl) (p=0.008) in the sesamin group compared to the placebo group.
 
Other Pharmacological Actions of Sesame Seeds
(This section in the original text is very brief and doesn't specify other actions, so I will maintain that brevity.)
 
➢ Safety Evaluations
  • Sesame is a traditional food known for its health benefits and is not only rich in oil (approximately 50%) and protein (around 20%) but also contains lignans, including sesamin and sesaminol (up to 1.5%).
  • The potential for sesamin and episesamin to cause genetic damage was assessed through various tests, including a bacterial reverse mutation assay (Ames test), a chromosomal aberration test in cultured Chinese hamster lung cells, a bone marrow micronucleus test in mice, and a comet assay using the liver of rats. The findings suggest that sesamin does not damage DNA in living organisms and that both sesamin and episesamin lack genotoxic activity.
 
Recommended Intake 200 mg per day for adults.
 
Available Product Specifications
  • Sesamum indicum extract complex available in concentrations of 70% and 90%.
  • Sesamum indicum extract standardized for sesamin content at 90% 1 and 95%.
 
Product Specifications..
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